Acne mainly affects your face, but it can also develop on your neck, back, chest, or shoulders. With acne, the pores in your skin become blocked by a buildup of skin cells and sebum oil.
This causes blackheads and whiteheads to develop. The sebum can also build up in your pores, leading to inflamed red and swollen papules and pus -filled pimples. A papule is a type of small bump. In more severe cases, larger nodules or cysts can form under the skin. Tazorac helps slow down the production of skin cells, so it helps stop your pores from getting clogged. The drug also reduces inflammation in your skin.
Tazorac cream was found to be effective for treating facial acne in two clinical studies. The drug reduced the number of inflammatory lesions red and swollen spots, pimples, or cysts and noninflammatory lesions blackheads and whiteheads. In these studies, researchers compared Tazorac cream with a placebo cream cream containing no active drug. Tazorac gel was also found to be effective for treating facial acne in two clinical studies.
As with the cream, the gel reduced the number of inflammatory and noninflammatory acne lesions. In these studies, researchers compared Tazorac gel with a placebo gel gel containing no active drug.
Both strengths 0. If your psoriasis is more widespread than this, your doctor will typically prescribe Tazorac cream. Plaque psoriasis is the most common form of an autoimmune condition known as psoriasis. With plaque psoriasis, your immune system mistakenly attacks your skin cells. This causes your skin cells to be replaced too quickly. The skin cells build up on the surface of your skin, creating silvery and scaly patches called plaques.
The plaques are often itchy and inflamed. They typically develop on your elbows, knees, lower back, and scalp. Tazorac helps slow down the production of skin cells. The drug reduces plaque formation, scaling, and inflammation in your skin. Researchers have looked at the effectiveness of Tazorac cream and gel in treating plaque psoriasis. Tazorac cream was found to be effective for treating plaque psoriasis in two clinical studies.
The drug reduced the thickness of the psoriasis plaques, as well as redness and scaling. They assessed how many people had clinical success with treatment. Clinical success was defined as having no, minimal, or mild psoriasis plaques.
In one of the studies, researchers also looked at how many people still had clinical success 12 weeks after stopping treatment. Clinical success was maintained in:. Tazorac gel was also found effective for treating plaque psoriasis in two clinical studies.
Similar to Tazorac cream, the gel reduced the thickness of the psoriasis plaques, as well as redness and scaling. In addition to the uses listed above, Tazorac may be used off-label for other uses. And you may wonder if Tazorac is used for certain other conditions. Below is information on other possible uses for Tazorac. However, another brand-name drug that contains tazarotene the active drug in Tazorac is approved for some of these purposes.
Studies have found that tazarotene can reduce fine wrinkles caused by sun damage. Other studies have also found that the drug can improve fine wrinkles, dark spots, skin roughness, and elasticity, and reduce pore size in sun-damaged skin. In fact, a brand-name medication containing 0.
Avage is approved to reduce fine facial wrinkles and certain types of dark or light spots on the face caused by sun damage. While you use Avage, you have to protect your skin from sunlight and follow a complete skin care routine that includes a moisturizer.
Acne can sometimes leave deep pitted scars. However, if Tazorac effectively treats your acne, this can help prevent acne scars from developing in the first place. Tazorac may also be used off-label to treat acne scars.
A small study found Tazorac 0. Microneedling is a treatment dermatologists use for various skin conditions. The 0. You may wonder how Tazorac compares with other medications that are prescribed for similar uses. Here we look at how Tazorac and Retin-A are alike and different. Tazorac contains tazarotene, while Retin-A contains tretinoin. Both Tazorac and Retin-A are retinoid medications. Tazorac comes as a cream and a gel.
Retin-A comes as a gel and a cream. The gel is available in two strengths: 0. The cream is available in three strengths: 0. Tazorac and Retin-A both contain a retinoid drug. Therefore, these medications can cause very similar side effects, but some different ones as well. Below are examples of these side effects.
This list contains up to 10 of the most common mild side effects that can occur with both Tazorac and Retin-A when used individually :. These lists contain examples of serious side effects that can occur with Tazorac, with Retin-A, or with both drugs when used individually. Tazorac and Retin-A were found to be similarly effective for treating acne in a recent review of studies. Current guidelines from the American Academy of Dermatology recommend both Tazorac and Retin-A as effective options for treating acne.
Talk with your doctor about which one is right for you. According to estimates on GoodRx. Like Retin-A above , the drug Differin has uses similar to those of Tazorac. Tazorac contains tazarotene, while Differin contains adapalene. Both are retinoid medications. Differin comes as a gel, cream, and lotion. These are all available in a strength of 0. The gel is also available in a 0. Tazorac and Differin both contain a retinoid drug.
This list contains up to 10 of the most common mild side effects that can occur with both Tazorac and Differin when used individually :. This list contains examples of serious side effects that can occur with both Tazorac and Differin when used individually :. A recent review of studies examined the use of topical applied to the skin retinoids in treating acne. The retinoids included Tazorac and Differin. However, they did find that Differin was linked to less bothersome side effects than other retinoids, including Tazorac.
Current guidelines from the American Academy of Dermatology recommend both Tazorac and Differin as effective options for treating acne. Tazorac can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Tazorac. For more information on the possible side effects of Tazorac, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.
Most of these side effects may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects.
Children ages 12 years and older may have the same side effects as adults who use Tazorac, such as those listed above. You may wonder how often certain side effects occur with this drug. As with most drugs, some people can have an allergic reaction after using Tazorac. Symptoms of a severe allergic reaction can include hives around your throat or on your tongue, or trouble breathing along with hives. If you develop these symptoms while using Tazorac, call or your local emergency number, or seek medical attention right away.
Some skin irritation may occur while using Tazorac. In fact, skin irritation was the most common side effect of Tazorac in clinical studies of the gel and cream. Skin irritation can be made worse by medications, cosmetics, and cosmetic treatments that have a drying or irritating effect on your skin. And avoid cosmetic treatments like waxing and chemical peels.
If your skin gets irritated while using Tazorac, talk with your doctor. Depending on how bad the irritation is, they may recommend using Tazorac less often, such as every other day. Or your doctor may suggest that you stop treatment for a time. You can usually start using Tazorac once a day again when your skin irritation eases.
If your skin gets irritated while using Tazorac 0. Skin may become more sensitive to sunlight, sun lamps, and tanning beds while using Tazorac. For fine wrinkling, the proportion of subjects who achieved improvement from baseline of at least 1 grade was significantly higher with 0. This significant difference over vehicle treatment was observed in all active retinoid groups except 0. The differences among the various active study medications those containing retinoids were only sporadically significant data not shown.
For mottled hyperpigmentation only, 0. Incidences of clinical improvement for the OIA of photodamage were significantly higher in the 0. The 0. Starting as early as week 8 and lasting through the posttreatment period, treatment success rates in the 0. Treatment success rates in the 0. Thus, the criterion of effectiveness, which stated that a 15—percentage point or greater difference between an active treatment group and a vehicle-treated group in the incidence of treatment success at week 24 would be considered clinically significant, was met by all treatment groups, except the 0.
Significant differences among the 6 treatment groups could also be shown at various time points for the following efficacy variables: lentigines, elastosis, and, to a lesser degree, irregular depigmentation data not shown.
No statistically significant differences among the 6 treatment groups could be shown for the following efficacy variables: coarse wrinkling, tactile roughness, pore size, and telangiectasia. The severity of actinic keratoses was decreased in all treatment groups. Baseline and posttreatment facial biopsy specimens were obtained in 31 subjects: 4 treated with 0. Examination of the baseline specimens by light microscopy revealed minimal cellular atypia in most of the subjects, which was consistent with the moderate degree of photodamage exhibited by the subjects.
After 24 weeks, all active treatments with topical retinoids increased the epidermal thickness. Topical retinoid treatment also appeared to result in more compact morphologic features of the stratum corneum, especially treatment with 0. Furthermore, all topical retinoid treatment resulted in an increase in the number of granular cell layers. No statistically significant changes were noted in cellular atypia, epidermal mucin level, dermal elastosis, perivascular inflammation, or type I collagen immunostaining.
Optical profilometric analysis of skin surface replicas revealed a modest decrease from baseline in surface roughness in all treatment groups. No statistically significant differences between the treatment groups were detected. Therapeutic drug monitoring was conducted at 2 centers during weeks 4 and Blood samples were collected from subjects before application of the study medication and 3 to 10 hours after application, to determine plasma concentrations of tazarotenic acid the active metabolite of tazarotene.
Results showed that the mean plasma tazarotenic acid concentrations generally increased with increasing strength of tazarotene cream. At week 24, plasma tazarotenic acid concentrations after application of the creams were 0. The highest individual plasma concentration detected was 0. Comparison of postdose concentrations during weeks 4 and 24 showed that the tazarotenic acid concentrations were not significantly different, indicating that drug accumulation did not occur.
Adverse events were reported by most patients [ Most of the reported adverse events were determined to be treatment related [ Although there was a relatively high incidence of treatment-related adverse events in subjects treated with the higher concentrations of tazarotene, the adverse events were generally mild to moderate. The most frequent adverse events were signs and symptoms of local skin irritation, such as mild to moderate desquamation, burning sensation, erythema, pruritus, and dry skin.
Such skin-associated adverse events are typical of topical retinoid therapy. Subjects were asked to evaluate their overall response to treatment compared with their condition at baseline at all follow-up visits, using a 5-point scale.
Significant differences among the treatments were noted from week 4 through week 26; 0. At the end of the study week 24 , subjects were asked to rate the cosmetic characteristics of the study medication they had been using. Significant differences in ratings were found for the "appearance of skin immediately before application," for which 0. When comparing the study medication with previously used photodamage therapies, subjects gave significantly higher ratings to the 0. In this double-blind investigator-masked comparison study, tazarotene was shown to be effective in the amelioration of the signs of photodamage.
Significant improvement compared with vehicle was seen for mottled hyperpigmentation as early as week 8 and for fine wrinkling as early as week 12 of this week study.
Overall, 0. As early as week 8, 0. Topical tazarotene also induced favorable histologic changes in photodamaged skin, similar to those described in an earlier pilot study and those described for tretinoin.
No increases in cellular atypia in either keratinocytes or melanocytes were observed with topical retinoid treatment. Optical profilometry, a method often proposed for the objective quantitative evaluation of facial wrinkles, 11 did not reveal any statistically significant differences among the various treatments used in this study.
The sample size 8 or 9 subjects per treatment group may have been too small. In an earlier week study 10 of the safety and efficacy of 0. Optical profilometry results also have been found to be consistent with clinical evaluations in reports 12 of the efficacy of 0.
Systemic exposure to tazarotenic acid, the active metabolite of tazarotene, following once-daily topical application of tazarotene-containing creams for the treatment of facial photodamage, appears to be limited. Results of therapeutic drug monitoring during this study showed that mean plasma concentrations of tazarotenic acid stayed low, although they increased with increasing strength of tazarotene cream, from 0. Although there was a relatively high incidence of treatment-related adverse events in the subjects treated with the higher concentrations of tazarotene, these adverse events were generally mild to moderate.
Most frequent were signs and symptoms of local irritation, and these were readily tolerated. Topical tazarotene improved photoaged skin like already established topical tretinoin. For fine wrinkling and mottled hyperpigmentation, 0. Although almost identical OIA improvement rates were seen with 0. Between the 0. The results of this study indicate that the synthetic retinoid tazarotene is safe and is associated with positive changes in the treatment of photodamaged facial skin.
Tazarotene cream reduces the severity of fine wrinkles and mottled hyperpigmentation and ameliorates the overall condition of photodamaged skin when compared with treatment with inactive vehicle cream. For local irritation, tazarotene was reasonably well tolerated, although somewhat more irritating at higher concentrations. We thank Paula M. Drs Kang, Leyden, Lowe, Ortonne, Phillips, and Weinstein were the investigators involved in the clinical study; Dr Bhawan evaluated the histologic samples obtained during the study; Drs Lew-Kaya, Sefton, Walker, and Gibson were all closely involved in the design of the study protocol and the monitoring of the clinical study; and Dr Matsumoto managed the therapeutic drug monitoring program of this study and analyzed the plasma samples.
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue. Figure 1. View Large Download. Differin is more aptly described as a retinoid-like compound, if we're being precise, but works the same way. Retin-A and Retin-A Micro are both brand names for tretinoin.
Retin-A Micro delivers the medication more slowly, over time, so it's less irritating than Retin-A. Like Retin-A, retinol is a topical retinoid. It's derived from vitamin A. It helps soften fine lines and brighten the skin. It doesn't work as quickly, nor does it work on the deeper layers of the skin like prescription retinoids do.
You can find retinol in many OTC anti-aging skincare products. Tretinoin and isotretinoin both are prescription medications used to treat acne. Both are derived from vitamin A. That's where their similarities stop.
Tretinoin is used topically to treat acne. Isotretinoin , better known by the now-defunct brand name Accutane , is an oral medication used to treat severe inflammatory acne. Tretinoin and isotretinoin are not interchangeable. Hopefully, you now have a better understanding of how Retin-A and tretinoin plus all those other sound-alike medications are related.
So many medications and brand names available have similar-sounding names. Some are completely interchangeable while others aren't, so it's important to keep them all straight. Your best source of information are the pros—your dermatologist and your pharmacist. Don't be afraid to ask questions. If you've been prescribed one medication but are given another, it's OK to question it pharmacists are humans too, so mistakes, while exceedingly rare, can be made.
At least your mind will be at ease, and you'll know exactly what you're putting on your skin and why. Also, ask your healthcare provider or dermatologist what to expect as you begin your Retin-A tretinoin treatment. That way you'll be prepared for any possible side effects and be ready to get the best results from your tretinoin treatment.
Dealing with acne can be frustrating. Our free guide provides expert tips to help you take control. Sign up and get yours today. Ortho-McNeil Pharmaceutical, Inc. Published June 10, Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. Retin-A Micro tretinoin Gel microsphere. Updated January
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